Just because everyone’s opting for Selective androgen receptor modulators (SARMs) doesn’t mean you should jump on the bandwagon of using them too.

But, if there’s a scientifically proven way to use a product for our betterment, it’s crucial not to give in to the misconceptions and take our physical and mental fitness up a notch.

Speaking of which, RAD-140 is known to be the safest and the most tolerated SARM there ever is. The word is, it could one day be used to treat many diseases and allow you to carve your dream body faster, but safer.

So, today, let’s set the record straight and find out all about its potential, and burst a few myths along the way.

But, you might want to strap in because there’s going to be a lot of good news about the king of SARMs!

A bit about RAD-140

Testolone or RAD 140 is of course an investigational SARM that is developed by Radius Health, Inc. especially for the purpose of use in androgen replacement therapy. 2 of the most common benefits of RAD-140 are being able to successfully treat muscle wasting and bone loss.

But, what does the research say? Glad you’ve asked.

According to an NCBI study, SARMs are in fact recognized to bind to androgen receptors differently, depending on how each SARM’s chemical structure is made of. In other words, Testolone might act differently than Ostarine.

The good news is, because of these different types of structures, SARMs result in anabolic cellular activity while dodging many side effects that are common for other widely available anabolic steroids. On the other hand, SARMs are known to be useful against breast cancer, cachexia and used as performance-enhancing agents.

As mentioned in another study, the reduction of testosterone levels in men during normal aging is one of the main culprits for skyrocketing the risks of dysfunction and disease in androgen-responsive tissues. This includes the brain.

But, the run-of-the-mill testosterone therapy can increase the risk of developing prostate cancer and worsening the already occurred cancers. So, testosterone therapy is like tossing more withered leaves into a bushfire.

This is why RAD-140 in particular has become one of the safest alternatives.

However, what does well-tolerated mean?

Simply put, if we take RAD-140 when https://www.canadasarms.com/wp-content/uploads/2021/02/AdobeStock_127797542-min-scaled-1.jpegistered the subjects can endure or resist the serious side effects or discomfort caused by the treatment, meaning it is an excellent substitute for usual drugs.

Why is RAD-140 the best-tolerated SARM?

1. RAD-140 can reduce cell death

A study that had been carried out to understand the benefits of Testolone has shown that it is pretty effective as testosterone in terms of reducing cell death induced by apoptotic insults.

These new findings suggest the initial preclinical efficacy of RAD-140’s neuroprotective actions towards potentially preventing Alzheimer’s disease (AD) and related neurodegenerative diseases.

Low testosterone in the brain is a focal factor for the escalation of Alzheimer’s disease, and circulating and brain levels of testosterone are quite lower in male patients with AD.

Right off the bat, it might be counterintuitive to think that this SARM helps save lives. But, as mentioned above, it will be possible to treat such diseases in the near future without the adverse effects of using testosterone.

2. RAD-140 is a potential treatment for Breast cancer

Any treatment for breast cancer or any other disease for that matter should be well-tolerated by the patients and should not aggravate its current state.

That being said, a study conducted in 2017 to investigate how RAD-140 acts as a treatment for breast cancer had shown a favorable response.

As a matter of fact, orally https://www.canadasarms.com/wp-content/uploads/2021/02/AdobeStock_127797542-min-scaled-1.jpegistrating Testolone had significantly hindered the growth of AR/ER+ breast cancer patient-derived xenografts (PDX).

This concludes that, in fact, RAD-140 is a promising treatment for AR/ER+ breast cancer patients and further clinical studies are highly encouraged.

Once more clinical studies on this SARM are performed, the breast cancer patients will have a real chance of starting the day with a new hope.

3. RAD-140 is a potential treatment for severe weight loss

Another study done in young, male cynomolgous monkeys to establish the effect of RAD140 has shown that a more than 10% mean weight gain had turned up in just under 28 days of dosing.

Not to mention, the dose was at just 0.1 mg/kg.

The researchers have also noted that RAD-140 has top-notch pharmacokinetics and is a potent anabolic in nonhuman primates too.

They have concluded that Testolone had shown an impressive preclinical profile, with completing preclinical toxicology in both monkeys and rats.

It is pleasing to see that this treatment will be used in patients suffering from severe weight loss as a result of cancer cachexia.

4. RAD-140 has shown anti-tumor activity

Last but not least, a brand-new study was done in 2021 to monitor the antitumor activity of RAD-140.

The goal of this first-in-human, phase 1 study was to determine whether this SARM is safe and tolerable. Moreover, the maximum tolerated dose (MTD), and the pharmacokinetic (PK) profile were also analyzed.

The study included 22 heavily pretreated (21 AR+) Metastatic Breast Cancer (MBC) patients. The dose levels were as 50 mg (n = 6), 100 mg (n = 13), and 150 mg (n = 3) given once, on a daily basis.

Not surprisingly, Testolone showed an acceptable safety profile as a treatment for AR+/ER+/HER2- mBC. The preliminary evidence suggests that this SARM is well-tolerated, and it displays a great deal of antitumor activity.

Verdict

Despite the fact that sometimes rumors get the better of consumers who are willing to try potential SARMs for their overall wellbeing, the results of these clinical studies speak for themselves.

Needless to say, they shed some light on Testolone regarding its potential to cure cancer, promote weight gain, antitumor activity, and dwindle cell death, etc.

But, the most important aspect is, in most studies, the researchers have conducted, RAD-140 seemed to be well-tolerated and that’s why further clinical investigations are highly suggested as well.

However, it all boils down to your preference and health.

On the other hand, if you fall for a bunch of baloney that fake companies often come up with while shopping for SARMs for sale in Canada, there’s a high chance you’ll be missing out on a lot of benefits that RAD-140 has to offer you.

So, as a rule of thumb, always lay hold of quality SARMs via a renowned provider such as the Canada SARMs.

References

1. https://en.wikipedia.org/wiki/RAD140
2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326857/
3. https://www.merriam-webster.com/dictionary/tolerate
4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018048/
5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959610/
6. https://pubmed.ncbi.nlm.nih.gov/28974548/
7. https://pubmed.ncbi.nlm.nih.gov/34565686/